Now that the sequences of many genomes are available, methods are required for the rapid identification of functional genes. We describe here a simple system for the isolation of genes that function ...

Rapid progress in the sequencing of several genomes has provided abundant sequence information, but the functions of many of the genes remain to be determined. So, a simple and reliable knockdown tool ...

Enzymes enable biochemical reactions that would otherwise not take place on their own. In nature, it is mostly proteins that function as enzymes. However, other molecules can also perform enzymatic ...

In new research published in the journal Angewandte Chemie, scientists applied a high throughput methodology to study the ribozyme in an innovative way. While work in this area has typically used ...

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure. A recent study ...

Molecular model showing an RNA strand from a hepatitis D virus genomic ribozyme, complexed with a ribonucleoprotein. Science Photo Library / Alamy Stock Photo A genomic screen has revealed a new ...

Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or "ribozyme," that carries out a fundamental reaction required to make new ...

The “RNA world” hypothesis proposes that the earliest life on Earth may have been based on RNA — a single-stranded molecule similar in many ways to DNA — like some modern viruses. This is because, ...

Ribozymes are RNA molecules that are capable of catalyzing a chemical reaction. Ribozymes occur naturally inside cells where they play an essential role in the ribosome, joining amino acids together ...

Researchers have visualized how a large RNA molecule assembles itself into a functional machine. RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like ...